简介：

白云峰，男，1981年出生，博士，教授，硕士生导师，美国普渡大学访问学者，山西省教学名师，现任农学与生命科学学院院长、化学生物传感山西省重点实验室副主任。近年来，获得山西省高等学校科学技术奖二等奖1项、山西省科学技术奖二等奖1项、山西省教学成果奖二等奖1项、山西大同大学研究生教育成果特等奖1项，主持省自然科学基金等省级科研项目9项，大同市科研项目2项，参与国家自然科学基金面上项目3项，省自然科学基金等省级项目10余项。主持省级教研项目2项，校级教研项目3项。发表学术论文100余篇，其中被SCI收录60余篇。申请国家发明专利20余项，已获授权国家发明专利16项，实用新型专利8项。

教育背景：

2000.09—2004.06  中国矿业大学  生物工程  学士

2004.09—2007.06  中国矿业大学  生物化工  硕士

2010.09—2014.07  山西师范大学  分析化学  博士

工作简历：

2007.08—2021.03    山西大同大学  化学与化工学院  助教，讲师，副教授

2017.06—2020.08    山西大同大学  化学与化工学院  副院长

2018.02—2019.03    美国普渡大学  访问学者

2019.12—至今      山西大同大学  化学生物传感山西省重点实验室  副主任

2020.08—2023.8    山西大同大学  地方产业服务中心  主任

2021.03—至今     山西大同大学  化学与化工学院  教授

2023.08—至今      山西大同大学  农学与生命科学学院  院长

代表性论文：

Yunfeng Bai, Feng Feng*, Lu Zhao, Chunyu Wang, Haiyan Wang, Maozhong Tian, Jun Qin, Yali Duan, Xiaoxiao He. Aptamer/thrombin/aptamer-AuNPs sandwich enhanced surface plasmon resonance sensor for the detection of subnanomolar thrombin. Biosensors and Bioelectronics, 2013, 47, 265-270.  SCI一区

Yunfeng Bai, Feng Feng*, Lu Zhao, Zezhong Chen, Haiyan Wang, Yali Duan. A turn-on fluorescent aptasensor for adenosine detection based on split aptamers and graphene oxide. Analyst, 2014, 139(8), 1843-1846.  SCI二区

Yunfeng Bai, Feng Feng*, Lu Zhao, Zezhong Chen, Haiyan Wang, Yali Duan. A label-free fluorescent sensor for Hg2+ based on target-induced structure-switching of G-quadruplex. Analytical Methods, 2014, 6(3), 662-665.  SCI三区

Yunfeng Bai, Lu Zhao, Zezhong Chen, Haiyan Wang, Feng Feng*. A label-free fluorescent sensor for Pb2+ based on G-quadruplex and graphene oxide. Analytical Methods, 2014, 6(20), 8120-8123.  SCI三区

Ya Zhang#, Yunfeng Bai#, Feng Feng*, Shaomin Shuang*. A graphene oxide-based fluorescent aptasensor for alpha-fetoprotein detection. Analytical Methods, 2016, 8: 6131-6134   SCI三区

Yunfeng Bai, Ruifang Zhao, Feng Feng*, Xiaoxiao He. Determination of Lysozyme by Thiol-Terminated Aptamer Based Surface Plasmon Resonance. Analytical Letters, 2017, 50(4): 682-689.  SCI四区

Haiyan Liu, Yunfeng Bai*, Jun Qin, Zezhong Chen, Feng Feng*. A novel fluorescent concanavalin A detection platform using anti-concanavalin A aptamer and graphene oxide. Analytical Methods, 2017, 9: 744-747.   SCI三区

Gai-Feng Kang, Yu-Zhen Wang*, Yun-Feng Bai*, Ze-Zhong Chen, Feng Feng*. Surface plasmon resonance based competitive immunoassay for Cd2+. RSC Advances, 2017, 7: 44054-44058.   SCI三区

Haiyan Liu, Yunfeng Bai*, Jun Qin, Haiyan Wang, Yuzhen Wang, Zezhong Chen, Feng Feng*. Exonuclease I assisted fluorometric aptasensor for adenosine detection using 2-AP modified DNA. Sensors and Actuators B: Chemical, 2018, 256: 413-419.   SCI一区

Yanyu Dai, Zhichao Liu, Yunfeng Bai*, Zezhong Chen, Jun Qin, Feng Feng*. A novel highly fluorescent S, N, O co-doped carbon dots for biosensing and bioimaging of copper ions in live cells. RSC Advances, 2018, 8(73): 42246-42252.   SCI三区

Yunfeng Bai, Zhuangzhuang Zhang, Lijun Cheng, Ruixin Wang, Xiaoliang Chen, Yifan Kong, Feng Feng, Nihal Ahmad, Lang Li, Xiaoqi Liu*. Inhibition of enhancer of zeste homolog 2 (EZH2) overcomes enzalutamide-resistance in castration-resistance prostate cancer. Journal of Biological Chemistry, 2019, 294(25): 9911-9923   SCI二区

Xiaoliang Chen, Lili Yin, Gan Qiao, Yanhua Li, Baoyuan Li, Yunfeng Bai*, Feng Feng*. Inhibition of Rac1 reverses enzalutamide resistance in castration‑resistant prostate cancer. Oncology Letters, 2020, 20(3): 2997-3005   SCI四区

Yunfeng Bai, Qian Su, Jimei Xiao, Feng Feng*, Xiaoming Yang*. Exploration of synthesizing fluorescent silicon nanoparticles and label-free detection of sulfadiazine sodium. Talanta, 2020, 220, 121410   SCI二区

Yunfeng Bai, Jie Liu, Feng Feng*, Xiaoming Yang*. Synthesis of folic acid-mediated copper nanoclusters for the detection of sulfadiazine sodium. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 605, 125376   SCI三区

Yunfeng Bai*, Huilin Zhang, Lu Zhao, Yuzhen Wang, Xiaoliang Chen, Hong Zhai, Maozhong Tian, Ruirui Zhao, Tao Wang, Hui Xu, Feng Feng*. A novel aptasensor based on HCR and G-quadruplex DNAzyme for fluorescence detection of Carcinoembryonic Antigen. Talanta, 2021, 221, 121451   SCI二区

Ruirui Zhao, Lu Zhao, Xiaoliang Chen, Haidi Feng, Huilin Zhang, Yunfeng Bai*, Feng Feng*, Shaomin Shuang*. A label-free fluorescence aptasensor based on HCR and G-quadruplex DNAzyme for the detection of prostate-specific antigen. Analyst, 2021, 146(4): 1340-1345   SCI二区

Chenxia Hao, Yunfeng Bai*, Zezhong Chen, Fanshen Geng, Jun Qin, Tao Zhou, Feng Feng*. Ultralong Room-Temperature Phosphorescence in Aqueous Medium from Silica Confined Polymer Carbon Dots for Multilevel Information Encryption. Dyes and Pigments, 2022, 197, 109890.  SCI二区

Chenxia Hao, Yunfeng Bai*, Lu Zhao, Yayan Bao, Jinai Bian, Hui Xu, Tao Zhou, Feng Feng*. Durable Room-Temperature Phosphorescence of Nitrogen-Doped Carbon Dots-Silica Composites for Fe3+ Detection and Anti-counterfeiting. Dyes and Pigments, 2022, 198, 109955  SCI二区

Zhiqiang Bai, Lu Zhao, Haidi Feng, Hui Xu, Nianping Zhang, Yanjun Li, Jinping Song, Yunfeng Bai*, Ronghua Yang*, Feng Feng*. Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer. Materials & Design, 2023, 226, 111656   SCI一区

Zhiqiang Bai, Lu Zhao, Haidi Feng, Zhihui Xin, Chaoyu Wang, Zhixiong Liu, Maozhong Tian, Haifei Zhang, Yunfeng Bai*, Feng Feng*. Aptamer modified Ti3C2 nanosheets application in smart targeted photothermal therapy for cancer, Cancer Nanotechnology, 2023, 14, 35  SCI二区

Haidi Feng, Lu Zhao, Zhiqiang Bai, Zhihui Xin, Chaoyu Wang, Lizhen Liu, Jinping Song, Haifei Zhang, Yunfeng Bai*, Feng Feng*. Aptamer modified Zr-based porphyrinic nanoscale metal–organic frameworks for active-targeted chemo-photodynamic therapy of tumors. RSC Advances, 2023, 13(6): 11215-11224    SCI三区

Xiaoliang Chen*, Lili Yin, Hui Xu, Jie Rong, Miao Feng, Di Jiang, Yunfeng Bai*. Knockdown of RhoA Expression Reverts Enzalutamide Resistance via the p38 MAPK Pathway in Castration-resistant Prostate Cancer. Recent Patents on Anti-Cancer Drug Discovery, 2023, 18(1): 92-99  SCI四区

Yuying Chen, Lu Zhao, Meiqing Liu, Xiaoliang Chen, Lihua Zhang, Hui Xu, Zezhong Chen, Aiai Wang, Yuzhen Wang*, Yunfeng Bai*, Feng Feng*. Aptamer-Functionalized Nanoscale Metal–Organic Frameworks for Targeted Photothermal-Chemo Combined Tumor Therapy. ACS Applied Nano Materials, 2024, 7(9), 10719-10730  SCI二区

Chaoyu Wang, Zhihui Xin, Zhiqiang Bai, Jiaxin Mao, Yaru Li, Zhifang Jia, Kewei Wang, Lu Zhao*, Yunfeng Bai*, Feng Feng*. A Covalent Organic Frameworks-based Nanoplatform with Enhanced Photothermal and Photodynamic Performance for Targeted Tumor Therapy. Materials Chemistry Frontiers, 2024, 8(16), 2736-2744   SCI二区

Meiqing Liu, Lu Zhao*, Yuying Chen, Xiaoliang Chen, Jiang Li, Zezhong Chen, Hui Xu, Yingying Zhao, Yunfeng Bai*, Feng Feng*. Aptamer-modified Nb2C multifunctional nanomedicine for targeted photothermal/chemotherapy combined therapy of tumor. Molecular Pharmaceutics, 2024, 21(8), 4047−4059   SCI二区

Tao Zhou, Chenxia Hao, Yunfeng Bai*, Pengli Chen, Tao Ma, Guifang Hong, Chenguang Yin, Feng Feng*. Multiple immobilized borate composites achieving color-tunable long afterglow in aqueous media for bioimaging and anti-counterfeiting. Microchemical Journal, 2024, 201, 110653  SCI二区

Ruirui Zhao, Yunfeng Bai*, Yujing Guo*, Feng Feng*, Shaomin Shuang*. Aptamer-Modified Tetrahedral DNA Nanostructures as Drug Delivery System for Cancer Targeted Therapy. Macromolecular Bioscience, 2024, 24(4), 2300420.  SCI四区

Zhihui Xin, Lu Zhao*, Zhiqiang Bai, Chaoyu Wang, Zhixiong Liu, Jun Qin, Lizhen Liu, Haifei Zhang, Yunfeng Bai*, Feng Feng*. Aptamer-functionalized hollow carbon nanospheres for targeted chemo-photothermal therapy of breast tumor. Materials Chemistry Frontiers, 2024, 8(24), 4049-4058  SCI二区

Yaru Li*, Lu Zhao, Jiali Wang, Long Ma*, Yunfeng Bai*, Feng Feng*. Argonaute-based nucleic acid detection technology: advantages, current status, challenges and perspectives. ACS Sensors, 2024, 9(11), 5665–5682  SCI一区

Yaru Li*, Lu Zhao, Long Ma*, Yunfeng Bai*, Feng Feng*. CRISPR/Cas and Argonaute-powered lateral flow assay for pathogens detection. Critical Reviews in Food Science and Nutrition, 2024, doi.org/10.1080/10408398.2024.2416473  SCI一区

Yaru Li*, Lu Zhao, Yunfeng Bai*, Feng Feng*. Applications of covalent organic frameworks (COFs)-based sensors for food safety: Synthetic strategies, characteristics and current state-of-art. Food Chemistry, 2025, 469, 142495  SCI一区

Yaru Li*, Lu Zhao, Long Ma*, Yunfeng Bai*, Feng Feng*. Argonaute protein powered biosensing for pathogenic biosafety. International Journal of Biological Macromolecules, 2025, 305, 141321  SCI一区

Lin Yuan, Lizhen Liu*, Yunfeng Bai*, Yuzhen Wang, Lu Zhao, Zhi Mi, Jun Qin, Feng Feng*. Ratiometric fluorescent and smartphone-assisted dual-mode sensor for folic acid determination based on N-Nb2C QDs/CQDs. Food Chemistry, 2025, 476, 143464   SCI一区

Yuzhen Wang*, Ningna Shi, Xiaoyue Kang, Qiliang Pan, Maozhong Tian, Yanfeng Wang, Yunfeng Bai*. Sensitive Competitive Electrochemical Immunosensor for Hg (II) Based on Molybdenum Disulfide/Reduced Graphene Oxide/Gold Nanocomposites. Sensors, 2025, 25(3), 623   SCI三区

Wenli Feng, Lu Zhao*, Chenxia Hao, Lin Yuan, Lizhen Liu, Xiaoming Yang*, Yunfeng Bai*, Feng Feng*. Ultra-stable room temperature phosphorescence CDs-based composite materials for anti-counterfeiting application. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 337, 126106  SCI二区

Zhihui Xin, Lu Zhao*, Jianfeng Li, Zhiqiang Bai, Yunfeng Bai*, Feng Feng*. Multifunctional nanozyme for tumor-targeted photothermal/catalytic combination therapy. Materials Chemistry Frontiers, 2025, 9(11), 1702–1715  SCI三区

Jianfeng Li, Zhihui Xin, Zhiqiang Bai, Jiang Li, Lu Zhao*, Yunfeng Bai*, Feng Feng*. A smart nanocomposite based on Mo2C MXene for active targeted photothermal-chemotherapy of cancer in NIR-II biowindows. ACS Biomaterials Science & Engineering, 2025, 11(6), 3307-3317  SCI三区

Yaru Li*, Lu Zhao, Wen Kang, Long Ma*, Yunfeng Bai*, Feng Feng*. Multiplexed CRISPR/Cas and Argonaute detection technology: strategies, challenges, and perspectives. Trends in Analytical Chemistry, 2025, 191, 118329  SCI一区

Lu Zhao#, Aiai Wang#, Yaru Li, Yunfeng Bai*, Feng Feng*. A smart Zr/Co porphyrin MOFs-based nanotheranostics: Triggering ROS storm for potentiated tumor therapy. Chemical Engineering Journal, 2025, 520, 165992  SCI一区，TOP期刊

Zhiqiang Bai, Lu Zhao*, Zhihui Xin, Jiang Li, Yunfeng Bai*, Feng Feng*. Smart therapeutic nanoplatform based on Ti3C2 MXenes for tumor targeted PTT/PDT/CHT at low temperatures. Molecular Pharmaceutics, 2025, 22(8), 4995-5006  SCI二区

Jing Tan, Zhiqiang Bai, Na Wu, Liangliang Wang, Yunfeng Bai*. Biopanning and design of RGD-modified phage displayed titanium-binding peptides with biofunctionality and binding stability. Biosurface and Biotribology, 2025, 11, e70010   SCI四区

Hui Xu, Lu Zhao*, Xiaoliang Chen, Zhiqiang Bai, Yanjun Li, Nianping Zhang, Yunfeng Bai*, Feng Feng*. PD-L1 aptamer-functionalized gold nanorods for targeted combined chemo-photothermal therapy in breast cancer. Bioconjugate Chemistry, 2025, 36(8), 1854-1864   SCI二区

Xiaoao Wang, Lu Zhao, Yunfeng Bai*, Feng Feng*. Studies on Ultralong Lifetime Room Temperature Phosphorescence from Crystals of Phenylpyridinyl Carbazoles. Crystal Growth & Design, 2025, 25(22), 9620-9629   SCI二区

Haizhen Lv, Zhiqiang Bai, Yanjun Li*, Lu Zhao*, Yunfeng Bai*, Feng Feng*. Enhanced therapeutic efficacy of folic acid-decorated Ti3C2 MXenes in targeted combination therapy for liver cancer. Materials Chemistry Frontiers, 2025, 9(22), 3323-3331  SCI三区

Yunfeng Bai, Haifei Zhang*. Freeze-enabled synthesis of functional materials: fundamental, progress, and applications. Progress in Materials Science, 2026, 155, 101523  SCI一区，TOP期刊

Lu Zhao#, Wenli Feng#, Chenxia Hao, Lin Yuan, Lizhen liu, Xiaoming Yang*, Yunfeng Bai*, Feng Feng*. Activating aqueous room temperature phosphorescence in N, S, B co-doped carbon dots for Fe3+ detection and anti-counterfeiting. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 348, 127243  SCI二区

Zhixiong Liu*, Xiaofang Zhao, Haobing Yang, Hongbin Yan, Kai Dong, Shuyu Wang, Zhen Lu, Yunfeng Bai*, Feng Feng. Transparent hydrophobic organoalkoxysilane-derived inorganic-organic hybrids for protecting sandstone. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 734, 139461  SCI二区

Hui Xu; Lu Zhao*; Xiaoliang Chen; Aiai Wang; Jianfeng Li; Yunfeng Bai*; Feng Feng*. Bioconjugate Chemistry, 2026, 37(2), 384-394  SCI二区

Lu Zhao#, Jianfeng Li#, Xuehui Zhang, Yunfeng Bai*, Feng Feng*. Molecular Pharmaceutics, 2026, doi.org/10.1021/acs.molpharmaceut.5c01663   SCI二区

课题研究：

基于空心碳纳米球的复合治疗系统对肿瘤主动靶向治疗的研究（2024054），大同市科技计划项目，2024.12—2026.12

基于PNMOFs的纳米治疗系统对肿瘤多模式靶向治疗的研究（20230036），山西省留学人员科技活动择优资助项目，2023.5—2026.5

基于MXenes和核酸适体的复合纳米治疗系统对肿瘤多模式靶向治疗的研究（202303021211324），山西省基础研究计划面上项目，2022.10—2025.10

基于适体功能化COFs的纳米载药系统用于多模式肿瘤治疗研究（2021L368），山西省高等学校科技创新项目，2021.9—2023.8

基于贵金属纳米簇和荧光碳点的肿瘤标志物检测新策略研究（2020-133），山西省省筹资金资助回国留学人员科研项目，2020.7—2023.7

基于功能核酸的光化学生物传感器研究（2020KJ023），山西省高等学校科学研究优秀成果培育项目，2020.6—2023.6

基于核酸适配体的肿瘤早期诊断新方法研究（2019L0735），山西省高科技开发项目，2019.7—2021.6

基于核酸适配体的肿瘤标志物检测新方法研究（201801D121035），山西省基础研究计划（自然科学基金），2018.12—2020.12

基于i-motif DNA和氧化石墨烯的生物传感新技术研究（2014020），化学生物传感与计量学国家重点实验室开放基金项目，2015.3—2017.3

i-motif DNA与氧化石墨烯的相互作用研究及其在生物传感领域中的应用（2015179），山西省高科技开发项目，2015.3—2017.3

基于i-motif DNA和氧化石墨烯的新型生物传感器研究（2015023），大同市工业科技攻关计划项目，2015.10—2017.12

基于功能核酸的新型生物传感器研究（2014-B-03），山西大同大学博士科研启动项目，2015.1—2017.12

获奖：

基于功能核酸的光化学生物传感器研究，山西省高等学校优秀成果奖（科学技术），自然科学奖二等奖，2020.6

基于信号放大技术的光化学生物传感研究，山西省科学技术奖，自然科学奖二等奖，2021.3

新建硕士学位授权单位研究生课程体系建设研究，山西省教学成果奖（高等教育），二等奖，2021.10

国家发明专利：

一种Fe/Mn 卟啉基双金属有机骨架及其制备方法和应用．国家发明专利，申请日期：2025.7.14. 申请号：CN202510967127.9

一种具有双酶活性的复合纳米材料及其制备方法和应用．国家发明专利，申请日期：2025.6.13. 申请号：CN202510793491.8

一种多功能肿瘤靶向低温治疗纳米平台及其应用．国家发明专利，授权日期：2025.11.11，专利号：ZL202510117488.4

一种多功能纳米酶及其制备方法和应用．国家发明专利，申请日期：2024.11.8. 申请号：CN202411592970.5

用于乳腺癌治疗的主动靶向纳米药物及其制备方法和应用．国家发明专利，申请日期：2024.4.26. 申请号：CN2024105148070

一种乳腺癌靶向纳米药物及其制备方法和应用．国家发明专利，申请日期：2024.4.22. 申请号：CN2024104853191

用于乳腺癌联合治疗的靶向纳米药物及其制备方法和应用．国家发明专利，申请日期：2024.4.22. 申请号：CN2024104853223

一种纳米靶向载药复合物及其制备方法和应用．国家发明专利，授权日期：2026.2.13，专利号：ZL202211049693.4

一种二氧化硅/氮掺杂碳纳米复合物及其制备方法与应用．国家发明专利，授权日期：2024.6.7，专利号：ZL202110812737.3

一种磷光二氧化硅/碳纳米复合物及其制备方法和应用．国家发明专利，授权日期：2024.4.9，专利号：ZL202110723231.5

基于杂交链式反应和核酶的荧光适配体传感器及其应用．国家发明专利，申请日期：2020.11.5，申请号：CN202011225724.8

基于杂交链式反应和核酶的传感器及癌胚抗原检测方法．国家发明专利，授权日期：2023.10.27，专利号：ZL202010080734.0

基于杂交链式反应的荧光DNA传感器及E542K基因检测方法．国家发明专利，授权日期：2022.9.9，专利号：ZL202010080730.2

一种N’-（喹啉-2-亚甲基）-7-二乙胺基香豆素-3-甲酰肼及其制备方法和应用．国家发明专利，授权日期：2018.5.4，专利号：ZL201510824122.7

荣誉：

优秀研究生指导教师，优秀教师，优秀教育工作者，优秀共产党员，优秀班主任，科研工作先进个人等。